Within PGENI there are 9 proposed regional centers. These regional centers are strategically located to provide support for all individual PGENI focus countries. It will be the regional centers responsibility to initiate and facilitate collaboration efforts with these individual countries that surround the regional center. Each regional center will have a primary investigator that will lead the areas PGENI efforts and concentrate on building collaborations in countries where none exist. With help from the individual countries, the regional centers will identify the ethnic groups within each country and obtain sample collection within those countries. Sample processing and genotyping will occur within these regional centers and will distribute the data to the individual countries and deposit them into the coordinating centers database. The regional centers will also provide an active network for the conduct of studies testing global pharmacogenetic hypotheses. Team members within the coordinating center will have varying responsibilities.